March 28, 2025
Activating Your Genes: Could This Be the Key to Wellness? with Dr. Christina Beer
Are you struggling to understand how nutrition impacts your genes and overall health?
Many people don't realize that what they eat can actually influence their DNA and cellular function. This lack of awareness may be preventing you from optimizing your health and wellness.
Discover how the emerging field of nutrigenomics can empower you to take control of your health at the cellular level.
BY THE TIME YOU FINISH LISTENING, YOU'LL LEARN:
- What nutrigenomics is and how it differs from traditional approaches to nutrition and medicine
- The key cellular pathways and mitochondrial function that impact oxidative stress, energy production, and metabolism
- How natural GLP-1 activation compares to popular weight loss medications
- Practical ways healthcare providers can start integrating nutrigenomics into patient care
This episode will open your eyes to the fascinating world of nutrigenomics and how it can transform your approach to health and wellness.
CONNECT WITH DR. CHRISTINA BEER
When you finish listening, I'd love to hear your biggest takeaway from today’s episode. Take a screenshot of you listening on your device, share it to your Instagram stories and tag me, @drtamarlawful!
WANT MORE?
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Chapters
00:00 - Understanding Oxidative Stress
06:58 - Dr. Baer's Journey Into Nutrigenomics
10:51 - From Symptoms to Cellular Activation
14:24 - The NRF2 Pathway Explained
19:39 - Mitochondria: More Than Cellular Batteries
24:56 - GLP-1: Beyond Weight Loss
29:09 - Natural GLP-1 System vs. Medications
32:46 - Integrating Nutrigenomics Into Pharmacy
40:17 - Ethics and Future of Nutrigenomics
46:12 - Key Takeaways and Closing Thoughts
Transcript
WEBVTT
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We don't want the production of ROS to get out of hand, because they're highly reactive molecules and they can damage your DNA.
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So if you understand the whole oxidative stress, then Nrf2 becomes much, much more important.
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If you want to break the mold of traditional pharmacy and healthcare, you are in the right place.
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Welcome to the Pivoting Pharmacy with Nutrigenomics podcast, part of the Pharmacy Podcast Network.
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Here's a little truth bomb.
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We're all unique, down to our DNA, so it's no wonder we react differently to the same medications, foods and environment.
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Here's a million dollar question how can you discover exactly what your body needs, which medication, what foods or supplements and which exercises are right for you?
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How can you manage chronic conditions like diabetes without more medications?
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How can you lose weight and keep it off?
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How do you tap into your genetic blueprints so you can stop surviving and start thriving in health and life?
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That is the question, and this podcast will give you the answer.
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I'm your host, dr Tamar, lawful doctor of pharmacy.
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Let's pivot into genomics and bring healthcare to higher levels.
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Hello, welcome back to Pivoting Pharmacy for Nutrigenomics.
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I'm your host, Dr.
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Tamar Lawful Doctor of Pharmacy and Certified Nutritional Genomics Specialist.
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Today we are incredibly fortunate to have Dr Christina Beer, a Senior Research Scientist at LifeVantage, join us on the show.
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With a rich background in nutrition, genetics and nutrigenomics, dr Behr stands at the forefront of scientific innovation, developing supplements aimed at optimizing cellular function and overall health.
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Her work doesn't just stay in a lab.
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It plays a pivotal role in bridging the gap between traditional healthcare and preventative, personalized wellness solutions.
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Dr Behr's focus on educating healthcare professionals, including pharmacists, on nutrigenomics allows for a more tailored approach to patient care.
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Her global experience and practical insights offer a unique perspective on how integrating personalized nutritional genomics can revolutionize mainstream healthcare.
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In this episode we'll dive into Dr Beer's journey into the world of nutrigenomics, her approach to simplifying complex scientific concepts for her patients and the potential challenges healthcare practitioners might face when integrating nutrigenomics into their practice.
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So stay tuned as we unravel the complexities of nutrigenomics with Dr Christina Beer.
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Listen in with Dr.
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Christina Beer.
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Listen in, Dr.
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Beer, welcome.
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Welcome to Pivoting Pharmacy with Nutrigenomics.
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I'm so excited to have you here today.
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I know that you're going to share a wealth of information with the audience listeners, and very rarely do I get to speak to somebody else that actually knows about Nutrigenomics, so definitely looking forward to our conversation.
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Yes, that's so nice.
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So, to kick it off, could you share a little bit about yourself, how you found your way into the world of nutrigenomics?
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Yeah, that's actually a really good question, because I don't know it myself, because I wasn't really looking for a journey into nutrigenomics, I just didn't know what I wanted to do.
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I didn't have looking for a journey into nutrigenomics, I just didn't know what I wanted to do.
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I didn't have no clue what my passion was in life.
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You know, you're kind of this you're out of high school, you're out of college or you're in your process of going to college and you don't really know what you want to do.
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Some people find it early in life.
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I found it a little later.
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I knew I wanted to stay in science.
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I've always liked science, so that was always exciting to me.
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So nutrigenomics kind of just landed in my lap.
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So even when I was a little girl I always wanted to know why certain things happen and my parents bought me a microscope that I can play with, and.
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But I never really focused on any science in particular.
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I knew I didn't want to be a business person or I wanted to do science, something with the body, and my first dream job was going to be a dentist.
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Then I was going to be a pediatrician and I actually started med school in Europe.
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I'm from Sweden, so I started med school in Europe, but then I kind of I was kind of lost in a way, until a friend of mine.
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He was majoring in microbiology in college and I thought, well, maybe my friends are all there, maybe I should give it a try, and that's when I instantly fell in love with it.
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It was all about the topic, the lab work, everything.
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And then the pivotal moment was when we had a food micro class.
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We had a lab with it and it really opened the eyes for me on what these little critters actually do for us and in our food and for our bodies.
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And then I went on to grad school learning everything about what food does to our biology and the saying you are what you eat somewhat became true, right.
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So I wanted to dig into that a little bit more, and maybe I'm dating myself right now, but the field of genetics was really new at the time.
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I was in college and looking at the genetic makeup of bacteria.
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So I was in the food science department and we were making cheese and we were altering the genetics of these little cheese starters that they call them, these little microorganisms that influence flavor, texture, aroma and all these things that make cheese.
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That's when I realized there's so much more we don't understand when it comes to food and bugs and how it influences our bodies.
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And then I learned about and we're close to a medical school, so we had a lot of presentations about genetic nutrition diseases such as phenylketonuria you know where you're lacking an enzyme that utilizes phenylalanine or the maple syrup disease, which is very similar, but just for branched chain amino acids.
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But I also learned that it's not a death sentence and that you can actually live with these diseases by making dietary changes.
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It was all so fascinating.
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So finding the field of nutrigenomics allowed me to actually follow that passion, develop foods or supplements that could influence your genes and allow the body to reach a state of balance, if they're not diseases but actually nutritional issues.
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So that's how I started in this field.
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Yeah, so curiosity went a long way.
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Very parallel to you, I had the microscope too growing up.
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I think that's our first initiation to science, right because I knew I liked science just like you and you're like science, so hey, why not get a microscope?
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so my mom got a microscope.
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I was always looking at slides underneath that microscope, yeah, and things on it and you look for the first.
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The first thing you look for is the onion peel.
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You know the onion layer and you see a little yes cell.
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So I think we all start with the same thing.
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It's amazing and science has come such a long way, and I love that.
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You said like looking at how the food impacts us on that cellular level.
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We are what we eat.
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It's a terminology that people hear a lot, but it's so true.
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So, when it comes to nutrigenomics, Dr.
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Beer, for our listeners who are actually new to the concept maybe this is their first time listening to the podcast but could you explain nutrigenomics in layman's terms?
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Yes, it's actually pretty simple.
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Nutrigenomics is a combination of two words.
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It uses nutrition, the nutri, and the word genome, which is our DNA collectively, our DNA in our cells.
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So it uses nutrition or food to influence our genes, our genome.
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It's pretty simple, yeah.
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Our food affects our genome, affects our DNA, affects us and many people when I have clients that I introduced to nutrigenomic testing too, they're surprised.
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This is a new concept to them, that what they eat actually affects them on a genetic level, but it is so true it does.
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Now, with your unique background in microbiology, nutrition and food science, Dr.
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Beer, how do you think this has affected your approach to nutrigenomics?
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I think there are two things that come to mind.
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First, I was raised in Sweden.
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At the time, we're almost all families I knew sat around the kitchen table.
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They ate breakfast and dinner as a family, and there was hardly ever any fast food or microwave food served.
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My mom cooked every night, so we cooked everything from scratch.
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We were outside, we played, we moved around.
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Then, when I came to the US, people were bigger.
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They ate more fast food, and I did too.
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Don't take me wrong, I did too.
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It was convenient, it was fast, it was delicious, it was actually really yummy.
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But then I realized and I was playing tennis at the time I realized that I didn't always feel good or happy after eating fast food.
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And I drank so much soda because all of a sudden it was free for all and my craving started to shift from a good savory dinner to a sugary, sweet dinner instead.
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So I started to realize something is going on.
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The second thing that comes to mind is that it's just fascinating with genetics.
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It's like wow, these little molecules can influence who you are and what you do.
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And I've read so much and learned so much about genetics from early on and I have a tendency to get lost in the details when learning new topics, and it was just amazing that when we eat plants, proteins or even candy, it influences our genes.
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In their response, they can produce chemicals that can make you feel happy or not so happy.
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And now we're actually capable of investigating what pathways and what genes are activated or not, whether activating this pathway is something we want and desirable, and what genes are activated or not, whether activating this pathway is something we want and desirable, and what genes are affected and not, and so on.
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It's just a fascinating topic.
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All in all, I think it is.
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It can be as complex as we want it to or simplified as we want it to, but it is indeed very complex when we think about it and also when it comes to the symptoms that people have, like you were mentioning.
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If you eat sugar, you might feel happy and then there are other foods that you can eat that might make you affect conditions.
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Nutrigenomics seems to shift our focus from just treating those symptoms to improving cellular health, to address underlying issues that people may have.
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What steps do you think are necessary to make this shift happen, where we're going from just treating symptoms to actually improving our cellular health?
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That's actually a very interesting question, and when you mentioned symptoms, I would assume that there's something wrong somewhere in the body.
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Right, Because if we're healthy, we don't have symptoms or issues.
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So when we treat symptoms, it does exactly what it says.
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It treats symptoms, but it doesn't go to the root cause of why we have these symptoms.
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You can have a headache or a bellyache or some other kind of aches and pains here and there, so you give them a painkiller right to treat that pain, but you're not looking at what caused the pain in the first place.
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So what we really want to do is look for the root cause and address this root cause.
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We want to empower your cells to take care of this root cause.
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We don't just want to cover it up.
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Sometimes, these cells we know that these cells need a little nudging, like a little here get started.
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Here is a kickstart to perform at their best, and this is what we call cellular activation.
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Best, and this is what we call cellular activation we will activate genes through the correct nutrient cocktail to perform at its best when it comes to addressing this root cause.
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Maybe you have clogged up the inside of your cells and need to clean it up.
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We can activate detox pathways now by providing the correct combination of botanicals, vitamins, minerals.
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Cellular activation allows your body to do just these things on its own.
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So there's a reason that it's so important to address this issue, because we just don't want to put a band-aid on it.
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We want to fix it long-term.
00:12:40.759 --> 00:12:43.546
Yes, indeed, we want to address those issues.
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No band-aids here at all.
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Now I want to get into maybe a couple pathways or systems that you focus on.
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I understand that activating the NRF2.
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When I say, I like to say NRF2, is that what you say?
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Pathway, yes, okay, this is a big part of your work, Dr.
00:13:01.081 --> 00:13:01.321
Beer.
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Why is this particular pathway so important for reducing oxidative stress?
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I will throw a question back before we talk about Nrf2, and that is do you really know what oxidative stress really means?
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I'm sure people have heard about oxidative stress and that it's bad for you, but do you really know what it means?
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So I'd like to go into the definition of oxidative stress first, before we can address Nrf2.
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Yes, let's do it, Okay.
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Oxidative stress means that there's somewhat of an imbalance between the production of free radicals in the body and we can call them ROS and the body's ability to neutralize them using antioxidants.
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So we don't want the production of ROS to get out of hand, because they're highly reactive molecules and they can bombard your cells and damage your cells.
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They can damage your proteins, your hormones, your lipids and they can damage your DNA.
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The thing is that we create them naturally, just by breathing and eating foods, and they can also be created from your environment, though the one we live in or your lifestyle.
00:14:10.114 --> 00:14:12.981
When you exercise, you create free radicals.
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When you smoke, free radicals enter your body.
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Aging can cause free radicals.
00:14:18.113 --> 00:14:27.014
So if you understand the whole oxidative stress, what that all means, then Nrf2 becomes much, much more important.
00:14:27.539 --> 00:14:34.073
So let's talk about Nrf2 then Nrf2 is just another name, and this is now very scientific.
00:14:34.073 --> 00:14:35.763
We have to put that in somehow.
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It's called nuclear factor erythroid 2 related factor 2.
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Nrf2 for short makes it simple and sweet.
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It's a transcription factor that plays a role in the body's defense against oxidative stress and inflammation.
00:14:49.504 --> 00:14:58.849
So a transcription factor is just a protein that helps regulate specific gene expressions and in this case nrf2 and antioxidants.
00:14:58.849 --> 00:15:11.095
So it helps genes that are involved in cell defenses, such as antioxidant responses, detoxification responses and maintenance of cellular balance.
00:15:11.975 --> 00:15:14.517
And under normal non-stress condition.
00:15:14.576 --> 00:15:24.602
Just you know, we're sitting here talking, we're not stressed.
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In a way, this Nrf2 factor or Nrf2 protein is tied up in the cell to another protein, so it can't do its thing.
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But when the cells are under stress, nrf2 is then released from this holding protein and travels to the nucleus, to your DNA, and on the DNA and this is the fascinating thing there's a region called antioxidant response element it's called ARE for short and when the Nrf2 protein binds to this region, it tells your DNA to activate the genes that are responsible for producing antioxidants, and I'm sure you've heard about antioxidants such as catalase, superoxide dismutase or SOD.
00:16:01.945 --> 00:16:10.727
There's other ones like hemoxygenase and a whole host of other ones that just have short abbreviations that are very complicated to remember.
00:16:10.727 --> 00:16:18.932
So, then, these antioxidants are released into the interior of the cells and counteract this oxidative stress moment.
00:16:18.932 --> 00:16:31.869
So that's why Nrf2 is so important Now, and as we age, we know that our antioxidant response to oxidative stress is not as efficient as it could be and needs a little help along the way.
00:16:31.869 --> 00:16:34.688
And that's where Nrf2 activation comes to play.
00:16:34.688 --> 00:16:39.399
So that's why we're so so invested in the Nrf2 pathway.
00:16:40.061 --> 00:16:47.753
And nutrigenomics would identify that perhaps genetically your response to oxidative stress is not that great.
00:16:47.812 --> 00:17:07.401
based on that transcription factor, yes, you may need some help because somewhere in your cell this nerve 2 may not be released as efficiently from the holding protein or it may not have the capability of getting through the nucleus membrane to bind to the DNA.
00:17:07.401 --> 00:17:09.266
So it may need a little help on the way.
00:17:10.067 --> 00:17:12.553
Okay, thank you for explaining that, Dr.
00:17:12.553 --> 00:17:12.673
Beer.
00:17:12.673 --> 00:17:19.701
I hope you guys are taking notes because this is so interesting, or not, or not, you can just replay or rewind.
00:17:19.701 --> 00:17:27.894
But that was an excellent explanation of oxidative stress and how the Nrf2 pathway is a big part of that.
00:17:27.894 --> 00:17:30.027
What about mitochondrial health?
00:17:30.027 --> 00:17:32.387
You know that's another area you emphasize a lot.
00:17:32.387 --> 00:17:33.779
Why is this so critical?
00:17:33.779 --> 00:17:40.377
How does improving mitochondrial function benefit our overall wellness, Dr.
00:17:40.377 --> 00:17:40.557
Beer?
00:17:41.500 --> 00:17:44.730
A mitochondria are fascinating little organelles in our cells.
00:17:44.730 --> 00:17:51.432
Indeed, they are, but do we really know what mitochondria do and what their functions are?
00:17:51.432 --> 00:17:58.073
So in order to answer that, maybe I should go back a little bit and talk about what mitochondria do.
00:17:58.073 --> 00:18:06.678
Yes, so mitochondria are basically the cell's powerhouse, because they're responsible for generating ATP.
00:18:06.678 --> 00:18:14.914
Without mitochondria, we actually will not be alive, and we may have heard about mitochondrial disease.
00:18:14.914 --> 00:18:23.705
I actually have a friend whose daughter has mitochondrial disease, and I'm seeing all these detrimental effects that are happening over time with her.
00:18:23.705 --> 00:18:36.570
So we want to make them as efficient as possible, and every cell in our body has mitochondria, except mature red blood cells, and that's only so that these blood cells can carry more oxygen.
00:18:36.570 --> 00:18:39.201
That's the only reason they've developed, not having mitochondria.
00:18:39.201 --> 00:18:49.865
But our cells don't only have one copy of mitochondria, they have many copies, and the cells that have the copies, and the cells that have the most, are the cells that work the hardest.
00:18:49.865 --> 00:18:52.791
And you can probably guess what they are.
00:18:52.791 --> 00:19:13.851
They're like our muscle cells, our liver, our heart, our brain cells, and they have the most copies of mitochondria because they're constantly turning over and they're constantly renewing themselves and and you use your heart's beating constantly and brain's going constantly and your muscles are always working so that you can stand upright or sitting down.
00:19:13.851 --> 00:19:22.961
So they have a lot of mitochondria and you can imagine if, if they don't have the efficiency of these mitochondria, there will be issues.
00:19:22.961 --> 00:19:25.491
But activating mitochondria or activating the ability to make more mitochondria, there will be issues.
00:19:25.511 --> 00:19:34.782
But activating mitochondria or activating the ability to make more mitochondria and thus allowing for more energy production is crucial and essential in the well-being of patients.
00:19:34.782 --> 00:19:38.130
So we know that they're really important for energy.
00:19:38.130 --> 00:19:41.884
But they also they're not just a battery for the cell.
00:19:41.884 --> 00:19:47.961
Their influence reaches so much further into the body for the cell.
00:19:47.961 --> 00:19:49.464
Their influence reaches so much further into the body.
00:19:49.464 --> 00:19:50.508
Yes, their primary function is to make energy.
00:19:50.508 --> 00:19:56.742
So if your mitochondria don't work correctly, you may experience chronic fatigue or muscle weakness.
00:19:56.742 --> 00:19:59.407
What about your brain cells?
00:19:59.848 --> 00:20:07.291
You may feel that you have a little bit of brain fog or your cognition is not where you think it should be.
00:20:07.291 --> 00:20:18.515
Heart health do we have enough energy to provide the heart cells with enough energy to beat properly and to repair the cells?
00:20:18.515 --> 00:20:22.980
Muscle cells we talked about them, Interestingly.
00:20:22.980 --> 00:20:29.905
Mitochondria help you regulate your metabolism, and that also includes conversion of food into energy.
00:20:29.905 --> 00:20:43.277
So it has a lot to do with your metabolism and weight management apps, actually, and disruption of this can lead to obesity, insulin resistance, diabetes and other sugar-related issues.
00:20:43.277 --> 00:20:54.030
It also has to do with immune cells and healing immunity and healing, because if these cells don't work correctly, you may have issues on your immune side.
00:20:54.471 --> 00:21:05.806
So, yes, there are batteries in every cell, but there are other co-hosts of issues that can be visible if they don't work appropriately.
00:21:05.806 --> 00:21:08.541
So that's the importance of mitochondria.
00:21:08.541 --> 00:21:17.926
But we also know that mitochondrial activation depends on another transcription factor that we call Nrf1, nuclear respiratory factor 1.
00:21:17.926 --> 00:21:29.602
So it works in a similar way as Nrf2, where it plays a role in gene expression of mitochondrial functions energy, metabolism and respiration.
00:21:29.602 --> 00:21:43.123
So Nrf1 is essential for the process of making new mitochondria within the cell and for making the associated proteins and lipids and carbohydrates needed for the mitochondrial function.
00:21:43.123 --> 00:21:44.786
So, as with Nr.
00:21:44.806 --> 00:21:58.307
Nerve, 2, mitochondria efficiency decreases with age and in order to get it back in as good of a balance as we can, we want to activate the mitochondrial pathway to support it.
00:21:59.028 --> 00:21:59.711
Lovely.
00:21:59.711 --> 00:22:01.614
The mitochondrial pathway.
00:22:01.614 --> 00:22:03.768
Mitochondrial function is so important.
00:22:03.768 --> 00:22:12.201
Pathway Mitochondria function is so important.
00:22:12.201 --> 00:22:17.573
There's so many different components on a cellular level that are critical for our health and the mitochondria is something we absolutely need.
00:22:17.573 --> 00:22:22.088
We need that to ourselves, we need it in essence.
00:22:22.769 --> 00:22:27.680
As one example mitochondria are the worst in creating oxidative stress.
00:22:27.680 --> 00:22:34.580
As we produce atp, we create oxidative free radicals, so then nerve two has to come in and help that out.
00:22:34.580 --> 00:22:39.884
So there's there's always a balance on how everything works together in the cell definitely.
00:22:40.066 --> 00:22:41.191
That's exactly what I'm trying to say.
00:22:41.191 --> 00:22:43.019
There is a balance in how everything works together.
00:22:43.019 --> 00:22:45.405
Thank you for explaining those that we've reviewed.
00:22:45.405 --> 00:22:51.306
The Nrf2, nrf1, mitochondrial health Now kind of a three-letter buzzword.
00:22:51.306 --> 00:22:54.553
I'll say that's out here lately, or GLP-1.
00:22:54.553 --> 00:23:02.473
So I want to talk about GLP-1 activation because it's gotten a lot of attention with its use now in medications for weight loss.
00:23:02.473 --> 00:23:11.007
Can you talk about why it's so beneficial, glp-1 activation, especially when it comes to the terms of weight?
00:23:11.028 --> 00:23:11.868
management and metabolic health.
00:23:11.868 --> 00:23:14.344
Yes, glp-1 is such a buzzword, it's everywhere.
00:23:14.344 --> 00:23:18.780
It seems like right, everywhere we turn around we see it on ads or billboards or somewhere.
00:23:18.780 --> 00:23:34.521
But the GLP-1, or glucagon-like peptide 1 hormone, the primary function of it is actually to regulate your body's how your body deals with glucose, right, so it's not specifically oh, it's going to cause me weight loss.
00:23:34.521 --> 00:23:36.347
So what it does?
00:23:36.347 --> 00:23:40.579
It balances your blood sugar response and your insulin response.
00:23:40.579 --> 00:23:56.912
But the cool thing is with GLP-1 is that it only enhances your insulin secretion when we experience a spike in glucose levels, like when we eat, right, but it doesn't spike just by sitting there.
00:23:56.912 --> 00:24:06.212
If we release, it stabilizes your blood sugar, but at the same time it also inhibits glucagon release from the pancreas.
00:24:06.212 --> 00:24:11.971
So glucagon is a hormone that usually signals the liver to release glucose if we need it, if we have too much insulin.
00:24:11.971 --> 00:24:15.566
So it helps reduce excessive glucose production in the liver.
00:24:15.566 --> 00:24:17.990
So it does a lot of things.
00:24:18.551 --> 00:24:25.895
It also talks to your stomach in a way, talks to the brain and to the stomach, and there's a combination, a back and forth talk all the time.
00:24:25.895 --> 00:24:27.520
So when it talks to the stomach and to the stomach, and there's a combination, a back and forth talk all the time.
00:24:27.520 --> 00:24:36.095
So when it talks to the stomach, it tells your stomach to slow down the speed at which your food leaves the stomach into the small intestine.
00:24:36.095 --> 00:24:37.787
So it slows gastric emptying.
00:24:37.787 --> 00:24:46.755
And this allows and helps slow down the absorption of sugar, of glucose, and contributes to a more stable sugar level after eating.
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